Literature Watch & News: Genitourinary Pathology (January 2022)
Sounak Gupta, MBBS, PhD and Rohit Mehra, MD.
Kidney Cancer
Association of High-Intensity Exercise with Renal Medullary Carcinoma in Individuals with Sickle Cell Trait: Clinical Observations and Experimental Animal Studies.
Cancers (Basel). 2021 Nov 30;13(23):6022. PMID: 34885132; PMCID: PMC8656882.
https://pubmed.ncbi.nlm.nih.gov/34885132/
Papillary renal cell carcinoma: a single institutional study of 199 cases addressing classification, clinicopathologic and molecular features, and treatment outcome.
Mod Pathol. 2021 Dec 23. Epub ahead of print. PMID: 34949764.
https://pubmed.ncbi.nlm.nih.gov/34949764/
Expanding the clinicopathological spectrum of succinate dehydrogenase-deficient renal cell carcinoma with a focus on variant morphologies: a study of 62 new tumors in 59 patients.
Mod Pathol. 2021 Dec 23. Epub ahead of print. PMID: 34949766.
https://pubmed.ncbi.nlm.nih.gov/34949766/
Oncocytic renal neoplasms with diffuse keratin 7 immunohistochemistry harbor frequent alterations in the mammalian target of rapamycin pathway. Mod Pathol. 2021 Nov 20. Epub ahead of print. PMID: 34802045.
https://pubmed.ncbi.nlm.nih.gov/34802045/
Development and validation of a vascularity-based architectural classification for clear cell renal cell carcinoma: correlation with conventional pathological prognostic factors, gene expression patterns, and clinical outcomes.
Mod Pathol. 2021 Nov 30. Epub ahead of print. PMID: 34848832.
https://pubmed.ncbi.nlm.nih.gov/34848832/
Assessment of Risk of Hereditary Predisposition in Patients With Melanoma and/or Mesothelioma and Renal Neoplasia.
JAMA Netw Open. 2021 Nov 1;4(11):e2132615. PMID: 34767027; PMCID: PMC8590170.
https://pubmed.ncbi.nlm.nih.gov/34767027/
Renal Neoplasia in Polycystic Kidney Disease: An Assessment of Tuberous Sclerosis Complex-associated Renal Neoplasia and PKD1/TSC2 Contiguous Gene Deletion Syndrome.
Eur Urol. 2021 Dec 4:S0302-2838(21)02161-8. Epub ahead of print. PMID: 34876325.
https://pubmed.ncbi.nlm.nih.gov/34876325/
Renal Neoplasia in Hyperparathyroidism-Jaw Tumor Syndrome.
Mayo Clin Proc . 2021 Oct;96(10):2730-2731. doi: 10.1016/j.mayocp.2021.08.011. PMID: 34607641
https://pubmed.ncbi.nlm.nih.gov/34607641/
Urinary Bladder Cancer
Different Responses to Neoadjuvant Chemotherapy in Urothelial Carcinoma Molecular Subtypes.
Eur Urol. 2021 Nov 12:S0302-2838(21)02138-2. Epub ahead of print. PMID: 34782206.
https://pubmed.ncbi.nlm.nih.gov/34782206/
International Bladder Cancer Group Consensus Statement on Clinical Trial Design for Patients with Bacillus Calmette-Guérin-exposed High-risk Non-muscle-invasive Bladder Cancer.
Eur Urol. 2021 Dec 23:S0302-2838(21)02213-2. Epub ahead of print. PMID: 34955291.
https://pubmed.ncbi.nlm.nih.gov/34955291/
Secondary malignancy after urologic reconstruction procedures: a multi-institutional case series.
Hum Pathol. 2021 Nov 19;119:69-78. Epub ahead of print. PMID: 34801602.
https://pubmed.ncbi.nlm.nih.gov/34801602/
TERT Promoter Mutations in Keratinizing and Nonkeratinizing Squamous Metaplasia of the Urinary Tract.
European Urology Open Science Volume 35, January 2022, Pages 74-78
https://www.sciencedirect.com/science/article/pii/S2666168321033851
Prostate Cancer
Targeting SWI/SNF ATPases in enhancer-addicted prostate cancer.
Nature. 2021 Dec 22. Epub ahead of print. PMID: 34937944.
https://pubmed.ncbi.nlm.nih.gov/34937944/
Defining the Impact of Family History on Detection of High-grade Prostate Cancer in a Large Multi-institutional Cohort.
Eur Urol. 2021 Dec 31. Epub ahead of print.
https://www.europeanurology.com/article/S0302-2838(21)02222-3/fulltext
High-intensity focused ultrasound for the treatment of prostate cancer: assessing location of failure after focal therapy in prostate cancer and review of histological characteristics and clinicopathologic correlates after treatment-a 5-year experience.
Hum Pathol. 2021 Nov 18;119:79-84. Epub ahead of print. PMID: 34801600.
https://pubmed.ncbi.nlm.nih.gov/34801600/
Prostatic Ductal Adenocarcinoma Controlled for Tumor Grade, Stage, and Margin Status Does Not Independently Influence the Likelihood of Biochemical Recurrence in Localized Prostate Cancer After Radical Prostatectomy.
Arch Pathol Lab Med. 2021 Nov 8. Epub ahead of print. PMID: 34739539.
https://pubmed.ncbi.nlm.nih.gov/34739539/
Variance of Tumor Grade at Radical Prostatectomy With Assessment of Each Tumor Nodule Versus Global Grading.
Arch Pathol Lab Med. 2021 Nov 9. Epub ahead of print. PMID: 34752602.
https://pubmed.ncbi.nlm.nih.gov/34752602/
Testis Cancer
Molecular assessment of testicular adult granulosa cell tumor demonstrates significant differences when compared to ovarian counterparts.
Mod Pathol. 2021 Nov 29. Epub ahead of print. PMID: 34845303.
https://pubmed.ncbi.nlm.nih.gov/34845303/
Large Cell Calcifying Sertoli Cell Tumour: A Contemporary Multi-Institutional Case Series Highlighting the Diagnostic Utility of PRKAR1A Immunohistochemistry.
Histopathology. 2021 Nov 15. Epub ahead of print. PMID: 34780072.
https://pubmed.ncbi.nlm.nih.gov/34780072/
Large Cell Calcifying Sertoli Cell Tumor: A Clinicopathologic Study of 18 Cases With Comprehensive Review of the Literature and Reappraisal of Prognostic Features.
Am J Surg Pathol. 2021 Dec 16. Epub ahead of print. PMID: 34913878.
https://pubmed.ncbi.nlm.nih.gov/34913878/
Penile Cancer
Lichen Sclerosus et Atrophicus With Histopathologic Features Mimicking Mycosis Fungoides: A Large Series of Cases Comparing Genital With Extragenital Lichen Sclerosus.
Am J Surg Pathol 2022 Jan 1;46(1):83-88. doi: 10.1097/PAS.0000000000001738.PMID: 34049317 https://pubmed.ncbi.nlm.nih.gov/34049317/
Digital Pathology/Artificial Intelligence
Real-time diagnosis and Gleason grading of prostate core needle biopsies using nonlinear microscopy.
Mod Pathol. 2021 Nov 2:1–10. Epub ahead of print. PMID: 34725447; PMCID: PMC8560363.
https://pubmed.ncbi.nlm.nih.gov/34725447/
A Hybrid Human-Machine Learning Approach for Screening Prostate Biopsies Can Improve Clinical Efficiency Without Compromising Diagnostic Accuracy.
Arch Pathol Lab Med. 2021 Sep 30. Epub ahead of print. PMID: 34591085.
Kidney Cancer
NF2-mutated Renal Carcinomas Have Common Morphologic Features Which Overlap With Biphasic Hyalinizing Psammomatous Renal Cell Carcinoma: A Comprehensive Study of 14 Cases.
Am J Surg Pathol. 2022 Jan 17. Epub ahead of print. PMID: 35034039.
https://pubmed.ncbi.nlm.nih.gov/35034039/
Adult Wilms Tumor: Genetic Evidence of Origin of a Subset of Cases From Metanephric Adenoma.
Am J Surg Pathol. 2022 Feb 21. Epub ahead of print. PMID: 35184066.
https://pubmed.ncbi.nlm.nih.gov/35184066/
Do we need an updated classification of oncocytic renal tumors? : Emergence of low-grade oncocytic tumor (LOT) and eosinophilic vacuolated tumor (EVT) as novel renal entities.
Mod Pathol. 2022 Mar 10. Epub ahead of print. PMID: 35273336.
https://pubmed.ncbi.nlm.nih.gov/35273336/
Renal cell carcinoma associated with tuberous sclerosis complex (TSC)/mammalian target of rapamycin (MTOR) genetic alterations.
Mod Pathol. 2022 Mar;35(3):296-297. Epub 2022 Jan 19. PMID: 35046523.
https://pubmed.ncbi.nlm.nih.gov/35046523/
Clinicopathological and molecular characterization of biphasic hyalinizing psammomatous renal cell carcinoma: further support for the newly proposed entity.
Hum Pathol. 2022 Feb 19:S0046-8177(22)00039-9. Epub ahead of print. PMID: 35192800.
https://pubmed.ncbi.nlm.nih.gov/35192800/
Renal cell carcinoma in children and adolescents: a retrospective study of a French-Italian series of 93 cases.
Histopathology. 2022 Mar 3. Epub ahead of print. PMID: 35238063.
https://pubmed.ncbi.nlm.nih.gov/35238063/
Pathology of Wilms’ tumour in International Society of Paediatric Oncology (SIOP) and Children’s oncology group (COG) renal tumour studies: Similarities and differences.
Histopathology. 2022 Mar 11. Epub ahead of print. PMID: 35275409.
https://pubmed.ncbi.nlm.nih.gov/35275409/
Granulomas associated with renal neoplasms: A multi-institutional clinicopathological study of 111 cases.
Histopathology. 2022 Mar 29. Epub ahead of print. PMID: 35347739.
https://pubmed.ncbi.nlm.nih.gov/35347739/
A Clinicopathological and Molecular Analysis of Fumarate Hydratase (FH)-deficient Renal Cell Carcinomas with Heterogeneous Loss of FH Expression.
Int J Surg Pathol. 2022 Jan 20:10668969221074600. Epub ahead of print. PMID: 35048731.
https://pubmed.ncbi.nlm.nih.gov/35048731/
Urinary Bladder Cancer
Different Responses to Neoadjuvant Chemotherapy in Urothelial Carcinoma Molecular Subtypes.
Eur Urol. 2021 Nov 12:S0302-2838(21)02138-2. Epub ahead of print. PMID: 34782206.
https://pubmed.ncbi.nlm.nih.gov/34782206/
International Bladder Cancer Group Consensus Statement on Clinical Trial Design for Patients with Bacillus Calmette-Guérin-exposed High-risk Non-muscle-invasive Bladder Cancer.
Eur Urol. 2021 Dec 23:S0302-2838(21)02213-2. Epub ahead of print. PMID: 34955291.
https://pubmed.ncbi.nlm.nih.gov/34955291/
Secondary malignancy after urologic reconstruction procedures: a multi-institutional case series.
Hum Pathol. 2021 Nov 19;119:69-78. Epub ahead of print. PMID: 34801602.
https://pubmed.ncbi.nlm.nih.gov/34801602/
TERT Promoter Mutations in Keratinizing and Nonkeratinizing Squamous Metaplasia of the Urinary Tract.
European Urology Open Science Volume 35, January 2022, Pages 74-78
https://www.sciencedirect.com/science/article/pii/S2666168321033851
Urinary Bladder Cancer
p53 null phenotype is a “positive result” in urothelial carcinoma in situ.
Mod Pathol. 2022 Mar 23. Epub ahead of print. PMID: 35322193.
https://pubmed.ncbi.nlm.nih.gov/35322193/
Molecular pathology of the non-luminal Ba/Sq-like and Sc/NE-like classes of urothelial tumours: An integrated immunohistochemical analysis. Hum Pathol.
2022 Jan 31;122:11-24. Epub ahead of print. PMID: 35108518.
https://pubmed.ncbi.nlm.nih.gov/35108518/
Reclassifying pT3 renal pelvic urothelial carcinoma with renal parenchyma invasion to pT2 improves correlation with overall survival.
Hum Pathol. 2022 Mar 17:S0046-8177(22)00065-X. Epub ahead of print. PMID: 35307402.
https://pubmed.ncbi.nlm.nih.gov/35307402/
MYC Amplification in Epithelioid Angiosarcoma of the Urinary Bladder and Prostate Following Prostate Radiotherapy: A Case Report with a Novel Molecular Alteration.
Int J Surg Pathol. 2022 Feb 21:10668969221081740. Epub ahead of print. PMID: 35188832.
https://pubmed.ncbi.nlm.nih.gov/35188832/
Muscle-invasive Bladder Cancer Arising After Prostate Radiotherapy: A Rare Entity with Unique Genomic Features.
Eur Urol. 2022 Jan 30:S0302-2838(22)00067-7. Epub ahead of print. PMID: 35109971.
https://pubmed.ncbi.nlm.nih.gov/35109971/
Prostate Cancer
Analysis of separate training and validation radical prostatectomy cohorts identifies 0.25 mm diameter as an optimal definition for “large” cribriform prostatic adenocarcinoma.
Mod Pathol. 2022 Feb 10. Epub ahead of print. PMID: 35145197.
https://pubmed.ncbi.nlm.nih.gov/35145197/
Risk Stratification of Prostatic Adenocarcinoma Metastatic to the Lymph Nodes. Arch Pathol Lab Med.
2022 Feb 10. Epub ahead of print. PMID: 35142822.
https://pubmed.ncbi.nlm.nih.gov/35142822/
The Clinical Impact of pT3a Lesions in Patients With pT3b Prostate Cancer Undergoing Radical Prostatectomy.
Arch Pathol Lab Med. 2022 Jan 3Epub ahead of print. PMID: 34979562.
https://pubmed.ncbi.nlm.nih.gov/34979562/
A Rare Germline HOXB13 Variant Contributes to Risk of Prostate Cancer in Men of African Ancestry.
Eur Urol. 2022 Jan 11:S0302-2838(21)02271-5. Epub ahead of print. PMID: 35031163.
https://pubmed.ncbi.nlm.nih.gov/35031163/
The Needle in the Haystack: The Presence of Castrate-resistant Prostate Cancer Cells in Hormone-naïve Prostate Cancer.
Eur Urol. 2022 Feb 24:S0302-2838(22)01609-8. Epub ahead of print. PMID: 35221165.
https://pubmed.ncbi.nlm.nih.gov/35221165/
Pre-existing Castration-resistant Prostate Cancer-like Cells in Primary Prostate Cancer Promote Resistance to Hormonal Therapy.
Eur Urol. 2022 Jan 17:S0302-2838(22)00001-X. Epub ahead of print. PMID: 35058087.
https://pubmed.ncbi.nlm.nih.gov/35058087/
Radical Prostatectomy Without Biopsy: Audacious, Imprudent, or Innovative?
Eur Urol. 2022 Mar 25:S0302-2838(22)01679-7. Epub ahead of print. PMID: 35346513.
https://pubmed.ncbi.nlm.nih.gov/35346513/
Testis Cancer
Sarcomatoid Yolk Sac Tumor Harbors Somatic Mutations That Are Otherwise Rare in Testicular Germ Cell Tumors.
Am J Surg Pathol. 2022 Jan 17. Epub ahead of print. PMID: 35034041.
https://pubmed.ncbi.nlm.nih.gov/35034041/
Cytogenetics of Spermatocytic Tumors with a Discussion of Gain of Chromosome 12p in “Anaplastic Variants”.
Hum Pathol. 2022 April1. Epub ahead of print.
https://www.sciencedirect.com/science/article/pii/S0046817722000788
Penile Cancer
HPV-negative Penile Intraepithelial Neoplasia (PeIN) With Basaloid Features.
Am J Surg Pathol. 2022 Mar 17. Epub ahead of print. PMID: 35297786.
https://pubmed.ncbi.nlm.nih.gov/35297786/
Pathological characterization and clinical outcome of penile intraepithelial neoplasia variants: a North American series.
Mod Pathol. 2022 Feb 21. Epub ahead of print. PMID: 35190664.
https://pubmed.ncbi.nlm.nih.gov/35190664/
Soft Tissue Tumors of the Genitourinary Tract
Clinicopathologic Features of Scrotal Leiomyosarcoma: Single Institutional Experience of Ten Cases.
Hum Pathol. 2022 April1. Epub ahead of print.
https://www.sciencedirect.com/science/article/pii/S0046817722000776